Abstract
Pyrazinamidase activity has been associated with pyrazinamide-susceptible Mycobacterium tuberculosis strains. The detection of pyrazinamidase activity by the Wayne method was found to be of limited value when compared with the results of standard pyrazinamide susceptibility tests, especially when a high level of pyrazinamide resistance was found. When resistance to pyrazinamide reached a level of 150 to 200 micrograms/ml, there was too much variability in Wayne test results to accurately define pyrazinamide susceptibility.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Pharmacology (medical),Pharmacology
Reference9 articles.
1. A simple way of detecting pyrazinamide resistance;Bander E.;Tubercle,1972
2. Improved method for testing susceptibility of Mycobacterium tuberculosis to pyrazinamide;Butler W. R.;J. Clin. Microbiol.,1982
3. Pyrazinamide susceptibility and amidase activity of tubercle bacilli;Konno K.;Am. Rev. Respir. Dis.,1967
4. Use of pyrazinamidase activity in Mycobacterium tuberculosis as a rapid method for determination of pyrazinamide susceptibility;McClatchy J. K.;Antimicrob. Agents Chemother.,1981
5. Activation of pyrazinamide and nicotinamide in acid environments in vitro;McDermott W.;Am. Rev. Tuberc.,1954
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