Affiliation:
1. Department of Microbiology and Immunology, University of Minnesota Medical School, Minneapolis, Minnesota, USA
Abstract
Pyrazinamide (PZA) is a cornerstone antimicrobial drug used exclusively for the treatment of tuberculosis (TB). Due to its ability to shorten drug therapy by 3 months and reduce disease relapse rates, PZA is considered an irreplaceable component of standard first-line short-course therapy for drug-susceptible TB and second-line treatment regimens for multidrug-resistant TB. Despite over 60 years of research on PZA and its crucial role in current and future TB treatment regimens, the mode of action of this unique drug remains unclear.
Funder
HHS | NIH | National Institute of Allergy and Infectious Diseases
Ford Foundation
HHS | NIH | National Heart, Lung, and Blood Institute
Publisher
American Society for Microbiology
Subject
Molecular Biology,Microbiology,Infectious Diseases
Cited by
42 articles.
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