Abrogation of the Interferon Response Promotes More Efficient Human Cytomegalovirus Replication-Reference-Cited by-同舟云学术

Abrogation of the Interferon Response Promotes More Efficient Human Cytomegalovirus Replication

Published:2015-01-15 Issue:2 Volume:89 Page:1479-1483
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

McSharry Brian P.¹,Forbes Simone K.¹²,Avdic Selmir¹,Randall Richard E.³,Wilkinson Gavin W. G.⁴,Abendroth Allison¹,Slobedman Barry¹

Affiliation:

1. Discipline of Infectious Diseases and Immunology, Sydney Medical School, University of Sydney, Camperdown, NSW, Australia

2. Centre for Virus Research, Westmead Millennium Institute, Westmead, NSW, Australia

3. School of Biology, University of St. Andrews, St. Andrews, United Kingdom

4. Department of Medical Microbiology, Cardiff Institute of Infection and Immunity, Cardiff University School of Medicine, Cardiff, United Kingdom

Abstract

ABSTRACT The effect of abrogating the interferon (IFN) response on human cytomegalovirus (HCMV) replication was investigated using primary human cells engineered to block either the production of or the response to type I IFNs. In IFN-deficient cells, HCMV produced larger plaques and spread and replicated more rapidly than in parental cells. These cells demonstrate the vital role of IFNs in controlling HCMV replication and provide useful tools to investigate the IFN response to HCMV.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.02988-14

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