The Cytomegalovirus M35 Protein Directly Binds to the Interferon-β Enhancer and Modulates Transcription of <i>Ifnb1</i> and Other IRF3-Driven Genes-Reference-Cited by-同舟云学术

The Cytomegalovirus M35 Protein Directly Binds to the Interferon-β Enhancer and Modulates Transcription of Ifnb1 and Other IRF3-Driven Genes

Published:2023-06-29 Issue:6 Volume:97 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Schwanke Hella¹²^ORCID,Gonçalves Magalhães Vladimir²^ORCID,Schmelz Stefan³^ORCID,Wyler Emanuel⁴^ORCID,Hennig Thomas⁵^ORCID,Günther Thomas⁶^ORCID,Grundhoff Adam⁶,Dölken Lars⁵,Landthaler Markus⁴⁷^ORCID,van Ham Marco⁸,Jänsch Lothar⁸⁹,Büssow Konrad³^ORCID,van den Heuvel Joop³^ORCID,Blankenfeldt Wulf³¹⁰^ORCID,Friedel Caroline C.¹¹^ORCID,Erhard Florian⁵^ORCID,Brinkmann Melanie M.¹²^ORCID

Affiliation:

1. Institute of Genetics, Technische Universität Braunschweig, Braunschweig, Germany

2. Virology and Innate Immunity Research Group, Helmholtz Centre for Infection Research, Braunschweig, Germany

3. Department Structure and Function of Proteins, Helmholtz Centre for Infection Research, Braunschweig, Germany

4. Berlin Institute for Medical Systems Biology, Max Delbrück Center for Molecular Medicine, Helmholtz Association, Berlin, Germany

5. Institute for Virology and Immunobiology, Julius-Maximilians-Universität Würzburg, Würzburg, Germany

6. Leibniz Institute of Virology, Hamburg, Germany

7. Institute for Biology, Humboldt-Universität zu Berlin, Berlin, Germany

8. Cellular Proteome Research Group, Helmholtz Centre for Infection Research, Braunschweig, Germany

9. Institute for Microbiology, Technische Universität Braunschweig, Braunschweig, Germany

10. Institute for Biochemistry, Biotechnology and Bioinformatics, Technische Universität Braunschweig, Braunschweig, Germany

11. Institute of Informatics, Ludwig-Maximilians-Universität München, Munich, Germany

Abstract

Replication of the ubiquitous human cytomegalovirus (HCMV) in healthy individuals mostly goes unnoticed but can impair fetal development or cause life-threatening symptoms in immunosuppressed or -deficient patients. Like other herpesviruses, CMV extensively manipulates its hosts and establishes lifelong latent infections.

Funder

Deutsche Forschungsgemeinschaft

Helmholtz Gemeinschaft

Helmholtz Protein Sample Production Facility

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/jvi.00400-23

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