The Interferon-Inducible Human PLSCR1 Protein Is a Restriction Factor of Human Cytomegalovirus-Reference-Cited by-同舟云学术

The Interferon-Inducible Human PLSCR1 Protein Is a Restriction Factor of Human Cytomegalovirus

Published:2022-02-23 Issue:1 Volume:10 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Sadanari Hidetaka¹,Takemoto Masaya²,Ishida Tomoki¹,Otagiri Hikaru¹,Daikoku Tohru¹,Murayama Tsugiya¹,Kusano Shuichi³^ORCID

Affiliation:

1. Department of Pharmaceutical Life Sciences, Faculty of Pharmaceutical Sciences, Hokuriku University, Ishikawa, Japan

2. Research Center for Pharmaceutical Education, Faculty of Pharmaceutical Sciences, Hokuriku University, Ishikawa, Japan

3. Division of Biological Information Technology, Joint Research Center for Human Retrovirus Infection, Kagoshima University, Kagoshima, Japan

Abstract

Because several IFN-stimulated genes (ISGs) have been reported to suppress HCMV replication, HCMV replication is thought to be regulated by an IFN-mediated host defense mechanism, but the mechanism remains unclear. PLSCR1 expression is induced in response to viral infection and IFN treatment, and PLSCR1 has been reported to play an important role in IFN-dependent antiviral responses.

Funder

Kodama Memorial Fund for Medical Research

MEXT | JSPS KAKENHI

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.01342-21

Reference53 articles.

1. Recent Advances in the Prevention and Treatment of Congenital Cytomegalovirus Infections

2. Clinical Aspects and Management of Cytomegalovirus Infection