Prohibitin-1 Contributes to Cell-to-Cell Transmission of Herpes Simplex Virus 1 via the MAPK/ERK Signaling Pathway

Author:

Watanabe Mizuki123,Arii Jun1245,Takeshima Kosuke12,Fukui Ayano12,Shimojima Masayuki6,Kozuka-Hata Hiroko7,Oyama Masaaki7,Minamitani Takeharu8,Yasui Teruhito8,Kubota Yuji9,Takekawa Mutsuhiro9,Kosugi Isao10,Maruzuru Yuhei12,Koyanagi Naoto124,Kato Akihisa124,Mori Yasuko5,Kawaguchi Yasushi124ORCID

Affiliation:

1. Division of Molecular Virology, Department of Microbiology and Immunology, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan

2. Department of Infectious Disease Control, International Research Center for Infectious Diseases, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan

3. Nippon Institute for Biological Science, Ome, Tokyo, Japan

4. Research Center for Asian Infectious Diseases, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan

5. Division of Clinical Virology, Center for Infectious Diseases, Kobe University Graduate School of Medicine, Kobe, Hyogo, Japan

6. Department of Virology I, National Institute of Infectious Diseases, Tokyo, Japan

7. Medical Proteomics Laboratory, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan

8. Laboratory of Infectious Diseases and Immunity, National Institutes of Biomedical Innovation, Health, and Nutrition, Ibaraki, Osaka, Japan

9. Division of Cell Signaling and Molecular Medicine, Department of Basic Medical Sciences, Institute of Medical Science, The University of Tokyo, Tokyo, Japan

10. Department of Regenerative and Infectious Pathology, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka, Japan

Abstract

Herpesviruses are ubiquitous pathogens of various animals, including humans. These viruses primarily pass through cell junctions to spread to uninfected cells.

Funder

Ichiro Kanehara Foundation

Japan Agency for Medical Research and Development

Ministry of Education, Culture, Sports, Science and Technology

MEXT | Japan Society for the Promotion of Science

Terumo Foundation for Life Sciences and Arts

Takeda Science Foundation

Kieikai Research Foundation

Kao Foundation for Arts and Sciences

Mitsubishi Foundation

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Reference74 articles.

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3. Herpes simplex virus glycoproteins E and I facilitate cell-to-cell spread in vivo and across junctions of cultured cells

4. Pellet PE, Roizman B. 2013. Herpesviridae, p 1802–1822. In Knipe DM, Howley PM, Cohen JI, Griffin DE, Lamb RA, Martin MA, Racaniello VR, Roizman B (ed), Fields virology, 6th ed. Lippincott-Williams & Wilkins, Philadelphia, PA.

5. Roizman B, Knipe DM, Whitley RJ. 2013. Herpes simplex viruses, p 1823–1897. In Knipe DM, Howley PM, Cohen JI, Griffin DE, Lamb RA, Martin MA, Racaniello VR, Roizman B (ed), Fields virology, 6th ed. Lippincott-Williams & Wilkins, Philadelphia, PA.

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