Affiliation:
1. Division of Clinical Virology, Center for Infectious Diseases, Kobe University Graduate School of Medicine, Kobe, Hyogo, Japan
Abstract
Human herpesvirus 6A (HHV-6A) is a ubiquitous herpesvirus implicated in Alzheimer’s disease, although its role in its pathogenesis has not been confirmed. Here, we showed that the transcription factor ATF1 restricts HHV-6A replication, mediated by IFN-β induction. Our study provides new insights into the role of ATF1 in innate viral immunity and reveals the importance of IFN-β for regulation of HHV-6A replication, which possibly impairs HHV-6A pathogenesis.
Funder
MEXT | Japan Society for the Promotion of Science
Ministry of Education, Culture, Sports, Science and Technology
Japan Agency for Medical Research and Development
Takeda Science Foundation
MSD Life Science Foundation, Public Interest Incorporated Foundation
CHUBEI ITOH foundation
Publisher
American Society for Microbiology
Subject
Virology,Insect Science,Immunology,Microbiology
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