A Homolog of the CtrA Cell Cycle Regulator Is Present and Essential in Sinorhizobium meliloti-Reference-Cited by-同舟云学术

A Homolog of the CtrA Cell Cycle Regulator Is Present and Essential in Sinorhizobium meliloti

Published:2001-05-15 Issue:10 Volume:183 Page:3204-3210
ISSN:0021-9193
Container-title:Journal of Bacteriology
language:en
Short-container-title:J Bacteriol

Author:

Barnett Melanie J.¹,Hung Dean Y.²,Reisenauer Ann³,Shapiro Lucy³,Long Sharon R.¹⁴

Affiliation:

1. Department of Biological Sciences,1

2. Department of Genetics,2

3. Department of Developmental Biology,3 and

4. Howard Hughes Medical Institute,4 Stanford University, Stanford, California 94305

Abstract

ABSTRACT During development of the symbiotic soil bacterium Sinorhizobium meliloti into nitrogen-fixing bacteroids, DNA replication and cell division cease and the cells undergo profound metabolic and morphological changes. Regulatory genes controlling the early stages of this process have not been identified. As a first step in the search for regulators of these events, we report the isolation and characterization of a ctrA gene from S. meliloti . We show that the S. meliloti CtrA belongs to the CtrA-like family of response regulators found in several α-proteobacteria. In Caulobacter crescentus , CtrA is essential and is a global regulator of multiple cell cycle functions. ctrA is also an essential gene in S. meliloti , and it is expressed similarly to the autoregulated C. crescentus ctrA in that both genes have complex promoter regions which bind phosphorylated CtrA.

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JB.183.10.3204-3210.2001

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