Affiliation:
1. Department of Molecular Microbiology, Centro de Investigaciones Biológicas, CSIC, Madrid, Spain
Abstract
ABSTRACT
The
pac
gene, encoding the penicillin G acylase from
Escherichia coli
W, is regulated by the PaaX repressor of the phenylacetate catabolic pathway.
pac
expression depends on the synthesis of phenylacetyl-coenzyme A. PaaX and the cyclic AMP receptor protein (CRP) bind in vitro to the
Ppac
promoter region. A palindromic sequence proposed as the PaaX operator is located upstream of the −35 box overlapping a CRP binding site, an unusual position that suggests a novel regulatory mechanism.
Publisher
American Society for Microbiology
Subject
Molecular Biology,Microbiology
Cited by
23 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献