MgrA Negatively Impacts Staphylococcus aureus Invasion by Regulating Capsule and FnbA-Reference-Cited by-同舟云学术

MgrA Negatively Impacts Staphylococcus aureus Invasion by Regulating Capsule and FnbA

Published:2019-12 Issue:12 Volume:87 Page:
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Lei Mei G.¹,Gudeta Dereje D.¹,Luong Thanh T.¹,Lee Chia Y.¹

Affiliation:

1. Department of Microbiology and Immunology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA

Abstract

Virulence genes are regulated by a complex regulatory network in Staphylococcus aureus . Some of the regulators are global in nature and affect many downstream genes. MgrA is a multiple-gene regulator that has been shown to activate genes involved in capsule biosynthesis and repress surface protein genes. The goal of this study was to demonstrate the biological significance of MgrA regulation of capsule and surface proteins.

Funder

HHS | NIH | National Institute of Allergy and Infectious Diseases

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.00590-19

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