Functional <i>mgrA</i> Influences Genetic Changes within a Staphylococcus aureus Cell Population over Time-Reference-Cited by-同舟云学术

Functional mgrA Influences Genetic Changes within a Staphylococcus aureus Cell Population over Time

Published:2022-10-18 Issue:10 Volume:204 Page:
ISSN:0021-9193
Container-title:Journal of Bacteriology
language:en
Short-container-title:J Bacteriol

Author:

Lee James¹²³,Carda-Diéguez Miguel⁴,Žiemytė Miglė⁴,Vreugde Sarah⁵,Cooksley Clare⁵,Crosby Heidi A.⁶,Horswill Alexander R.⁶^ORCID,Mira Alex⁴,Zilm Peter S.⁷,Kidd Stephen P.¹²³^ORCID

Affiliation:

1. Department of Molecular and Biomedical Sciences, School of Biological Sciences, The University of Adelaide, Adelaide, South Australia, Australia

2. Research Centre for Infectious Disease (RCID), The University of Adelaide, Adelaide, South Australia, Australia

3. Australian Centre for Antimicrobial Resistance Ecology (ACARE), The University of Adelaide, Adelaide, South Australia, Australia

4. Department of Health and Genomics, Center for Advanced Research in Public Health, FISABIO Foundation, Valencia, Spain

5. Department of Otolaryngology, Head and Neck Surgery, Basil Hetzel Institute, South Australia, Adelaide, Australia

6. Department of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, Colorado, USA

7. Adelaide Dental School, The University of Adelaide, Adelaide, South Australia, Australia

Abstract

Within a bacterial population, a stochastically generated heterogeneity of phenotypes allows continual survival against current and future stressors. The generation of a sub-population of quasi-dormant Small Colony Variants (SCV) in Staphylococcus aureus is such a mechanism, allowing for persistent or relapse of infection despite initial intervention seemingly clearing the infection.

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/jb.00138-22

Reference58 articles.

1. Staphylococcus aureus Infections: Epidemiology, Pathophysiology, Clinical Manifestations, and Management

2. Staphylococcus aureus phenotype switching: an effective bacterial strategy to escape host immune response and establish a chronic infection

3. Persistent and Relapsing Infections Associated with Small-Colony Variants of Staphylococcus aureus

4. Small colony variants: a pathogenic form of bacteria that facilitates persistent and recurrent infections

5. Phenotype Switching Is a Natural Consequence of Staphylococcus aureus Replication

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