Functional mgrA Influences Genetic Changes within a Staphylococcus aureus Cell Population over Time

Author:

Lee James123,Carda-Diéguez Miguel4,Žiemytė Miglė4,Vreugde Sarah5,Cooksley Clare5,Crosby Heidi A.6,Horswill Alexander R.6ORCID,Mira Alex4,Zilm Peter S.7,Kidd Stephen P.123ORCID

Affiliation:

1. Department of Molecular and Biomedical Sciences, School of Biological Sciences, The University of Adelaide, Adelaide, South Australia, Australia

2. Research Centre for Infectious Disease (RCID), The University of Adelaide, Adelaide, South Australia, Australia

3. Australian Centre for Antimicrobial Resistance Ecology (ACARE), The University of Adelaide, Adelaide, South Australia, Australia

4. Department of Health and Genomics, Center for Advanced Research in Public Health, FISABIO Foundation, Valencia, Spain

5. Department of Otolaryngology, Head and Neck Surgery, Basil Hetzel Institute, South Australia, Adelaide, Australia

6. Department of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, Colorado, USA

7. Adelaide Dental School, The University of Adelaide, Adelaide, South Australia, Australia

Abstract

Within a bacterial population, a stochastically generated heterogeneity of phenotypes allows continual survival against current and future stressors. The generation of a sub-population of quasi-dormant Small Colony Variants (SCV) in Staphylococcus aureus is such a mechanism, allowing for persistent or relapse of infection despite initial intervention seemingly clearing the infection.

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3