Transcriptome and Proteome of Methicillin-Resistant Staphylococcus aureus Small-Colony Variants Reveal Changed Metabolism and Increased Immune Evasion

Author:

Liu Si1,Chen Hongbin1ORCID,Chen Juan12,Wang Tianyi3,Tu Shangyu1,Zhang Xiaoyang1,Wang Qi1,Yin Yuyao1,Zhang Yawei1,Wang Xiaojuan1,Zhao Chunjiang1,Wang Hui1ORCID

Affiliation:

1. Department of Clinical Laboratory, Peking University People’s Hospital, Beijing, China

2. Department of Clinical Laboratory, The Affiliated Qingdao Central Hospital of Qingdao University, Qingdao, Shandong, China

3. Peking University Health Science Center, Beijing, China

Abstract

Small-colony variants (SCVs) of Staphylococcus aureus have drawn increasing research attention. Owing to their slow growth, atypical colony morphology, and unusual metabolic characteristics, SCVs often cause confusion in the laboratory.

Funder

National Natural Science Foundation of China

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

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