Adaptation of Mycobacterium tuberculosis to Biofilm Growth Is Genetically Linked to Drug Tolerance-Reference-Cited by-同舟云学术

Adaptation of Mycobacterium tuberculosis to Biofilm Growth Is Genetically Linked to Drug Tolerance

Published:2019-11 Issue:11 Volume:63 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Richards Jacob P.¹²,Cai Wenlong³⁴,Zill Nicholas A.³⁴,Zhang Wenjun³⁴,Ojha Anil K.¹²⁵

Affiliation:

1. Division of Genetics, Wadsworth Center, New York State Department of Health, Albany, New York, USA

2. Department of Infectious Diseases and Microbiology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA

3. Department of Chemical and Biomolecular Engineering, University of California, Berkeley, California, USA

4. Chan Zuckerberg Biohub, San Francisco, California, USA

5. Department of Biomedical Sciences, University at Albany, Albany, New York, USA

Abstract

Mycobacterium tuberculosis spontaneously grows at the air-medium interface, forming pellicle biofilms, which harbor more drug-tolerant persisters than planktonic cultures. The underlying basis for increased persisters in M. tuberculosis biofilms is unknown.

Funder

HHS | NIH | NIH Office of the Director

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.01213-19

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