Characterization of <i>Mycobacterium abscessus</i> colony-biofilms based on bi-dimensional images-Reference-Cited by-同舟云学术

Characterization of Mycobacterium abscessus colony-biofilms based on bi-dimensional images

Published:2023-09-19 Issue:9 Volume:67 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Aguilera-Correa John Jairo¹^ORCID,Boudehen Yves-Marie¹,Kremer Laurent¹²^ORCID

Affiliation:

1. Centre National de la Recherche Scientifique UMR 9004, Institut de Recherche en Infectiologie de Montpellier (IRIM), Université de Montpellier , Montpellier, France

2. INSERM, IRIM , Montpellier, France

Abstract

ABSTRACT Mycobacterium abscessus biofilm aggregates have been shown in the lungs of cystic fibrosis patients and are often tolerant to drugs. Herein, we analyzed bi-dimensional images of either fluorescent or Congo red-stained M. abscessus colony-biofilms grown on a membrane to monitor growth and shape of M. abscessus smooth and rough variants. These colony-biofilms responded differently to rifabutin and bedaquiline, thus highlighting the importance of the morphotype to properly address antibiotic treatment in patients with biofilm-related infections.

Funder

Agence Nationale de la Recherche

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/aac.00402-23

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