Formaldehyde-Responsive Proteins TtmR and EfgA Reveal a Trade-off between Formaldehyde Resistance and Efficient Transition to Methylotrophy in Methylorubrum extorquens-Reference-Cited by-同舟云学术

Formaldehyde-Responsive Proteins TtmR and EfgA Reveal a Trade-off between Formaldehyde Resistance and Efficient Transition to Methylotrophy in Methylorubrum extorquens

Published:2021-04-08 Issue:9 Volume:203 Page:
ISSN:0021-9193
Container-title:Journal of Bacteriology
language:en
Short-container-title:J Bacteriol

Author:

Bazurto Jannell V.¹²³⁴⁵,Bruger Eric L.¹²³,Lee Jessica A.¹²³⁶,Lambert Leah B.¹,Marx Christopher J.¹²³^ORCID

Affiliation:

1. Department of Biological Sciences, University of Idaho, Moscow, Idaho, USA

2. Insititute for Modeling Collaboration and Innovation, University of Idaho, Moscow, Idaho, USA

3. Institute for Bioinformatics and Evolutionary Studies, University of Idaho, Moscow, Idaho, USA

4. Department of Plant and Microbial Biology, University of Minnesota, Twin Cities, Minnesota, USA

5. Microbial and Plant Genomics Institute, University of Minnesota, Twin Cities, Minnesota, USA

6. NASA Ames Research Center, Moffett Field, California, USA

Abstract

All organisms produce formaldehyde as a by-product of enzymatic reactions and as a degradation product of metabolites. The ubiquity of formaldehyde in cellular biology suggests all organisms have evolved mechanisms of mitigating formaldehyde toxicity.

Funder

DOD | United States Army | RDECOM | Army Research Office

HHS | National Institutes of Health

National Science Foundation

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JB.00589-20

Reference59 articles.

1. Methenyl-Dephosphotetrahydromethanopterin Is a Regulatory Signal for Acclimation to Changes in Substrate Availability in Methylobacterium extorquens AM1