C 1 Transfer Enzymes and Coenzymes Linking Methylotrophic Bacteria and Methanogenic Archaea

Author:

Chistoserdova Ludmila1,Vorholt Julia A.1,Thauer Rudolf K.1,Lidstrom Mary E.1

Affiliation:

1. L. Chistoserdova, Department of Chemical Engineering, University of Washington, Seattle, WA 98195, USA. J. A. Vorholt and R. K. Thauer, Department of Biochemistry, Max-Planck-Institute for Terrestrial Microbiology, Marburg 35043, Germany. M. E. Lidstrom, Department of Chemical Engineering, Department of Microbiology, University of Washington, Seattle, WA 98195, USA.

Abstract

Methanogenic and sulfate-reducing Archaea are considered to have an energy metabolism involving C 1 transfer coenzymes and enzymes unique for this group of strictly anaerobic microorganisms. An aerobic methylotrophic bacterium, Methylobacterium extorquens AM1, was found to contain a cluster of genes that are predicted to encode some of these enzymes and was shown to contain two of the enzyme activities and one of the methanogenic coenzymes. Insertion mutants were all unable to grow on C 1 compounds, suggesting that the archaeal enzymes function in aerobic C 1 metabolism. Thus, methylotrophy and methanogenesis involve common genes that cross the bacterial/archaeal boundaries.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference31 articles.

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5. ; R. Thauer Antonie Leeuwenhoek 71 21 (1997).

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