Iron-Dependent Regulation of Molybdenum Cofactor Biosynthesis Genes in Escherichia coli-Reference-Cited by-同舟云学术

Iron-Dependent Regulation of Molybdenum Cofactor Biosynthesis Genes in Escherichia coli

Published:2019-09 Issue:17 Volume:201 Page:
ISSN:0021-9193
Container-title:Journal of Bacteriology
language:en
Short-container-title:J Bacteriol

Author:

Zupok Arkadiusz¹,Gorka Michal²,Siemiatkowska Beata²,Skirycz Aleksandra²,Leimkühler Silke¹

Affiliation:

1. Institute of Biochemistry and Biology, Molecular Enzymology, University of Potsdam, Potsdam-Golm, Germany

2. Max Planck Institute of Molecular Plant Physiology, Potsdam-Golm, Germany

Abstract

FNR is a very important transcriptional factor that represents the master switch for the expression of target genes in response to anaerobiosis. Among the FNR-regulated operons in Escherichia coli is the moaABCDE operon, involved in Moco biosynthesis. Molybdoenzymes have essential roles in eukaryotic and prokaryotic organisms. In bacteria, molybdoenzymes are crucial for anaerobic respiration using alternative electron acceptors. This work investigates the connection of iron availability to the biosynthesis of Moco and the production of active molybdoenzymes.

Funder

Deutsche Forschungsgemeinschaft

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JB.00382-19

Reference79 articles.

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