Affiliation:
1. University of Alabama Medical Center, Division of Nutrition and Department of Biochemistry, Birmingham, Alabama 35233
Abstract
Corynebacterium
species lacks the ability to convert either xanthine or guanine to adenine. This defect and the use of the purine nucleoside antibiotic decoyinine, which blocks the conversion of xanthosine monophosphate → guanosine monophosphate, permit an experimental design in which the interconversion of purines is largely prevented. Cultures of this organism were grown in the presence of decoyinine and various purine supplements. Data obtained by comparing the radioactivity incorporated from guanine-
2
-
14
C
or xanthine-
2
-
14
C
into bacterial guanine, xanthine, and riboflavine indicate that guanine or a close derivative of guanine is the purine precursor of riboflavine.
Publisher
American Society for Microbiology
Subject
Molecular Biology,Microbiology
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