Affiliation:
1. Servicio de Micologia, Centro Nacional de Microbiologia, Instituto de Salud Carlos III, Majadahonda, Madrid, Spain
Abstract
ABSTRACT
This study analyzed 28
Aspergillus
strains belonging to the section
Fumigati
that were isolated from clinical samples in Spain. All isolates sporulated slowly and were unable to grow at 48°C. Phylogenetic analysis based on sequencing of partial sequences of the β-tubulin and rodlet A genes was used to classify the 28 strains into six different clades (
Neosartorya hiratsukae
,
Neosartorya pseudofischeri
,
Aspergillus viridinutans
,
Aspergillus lentulus
,
Aspergillus fumigatiaffinis
, and
Aspergillus fumisynnematus
). Antifungal susceptibility testing showed heterogeneous patterns and grouped the strains together by species. Most
A. lentulus
and
A. fumigatiaffinis
isolates showed high MICs of amphotericin B (geometric mean [GM] MICs, ≥4.5 μg/ml), itraconazole (GM MICs, ≥6 μg/ml), voriconazole (GM MICs, ≥3 μg/ml), and ravuconazole (GM MICs, ≥3 μg/ml);
N pseudofischeri
and
A. viridinutans
showed high MICs of itraconazole (GM MICs, ≥8 μg/ml), voriconazole (GM MICs, ≥3.33 μg/ml), and ravuconazole (GM MICs, ≥2 μg/ml); and
N. hiratsukae
and
A. fumisynnematus
were susceptible to all the antifungals tested. In conclusion, a number of different species whose morphological features resemble those of
Aspergillus fumigatus
could succeed in producing invasive infections in the susceptible host. In addition, some of them showed high MICs for most of the antifungals available for the treatment of patients infected with these organisms. The epidemiology and clinical relevance of these species should therefore be addressed.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Pharmacology (medical),Pharmacology
Cited by
222 articles.
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