Effect of SUMO-SIM Interaction on the ICP0-Mediated Degradation of PML Isoform II and Its Associated Proteins in Herpes Simplex Virus 1 Infection-Reference-Cited by-同舟云学术

Effect of SUMO-SIM Interaction on the ICP0-Mediated Degradation of PML Isoform II and Its Associated Proteins in Herpes Simplex Virus 1 Infection

Published:2020-06 Issue:12 Volume:94 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Jan Fada Behdokht¹,Kaadi Elie¹,Samrat Subodh Kumar¹,Zheng Yi¹,Gu Haidong¹

Affiliation:

1. Department of Biological Sciences, Wayne State University, Detroit, Michigan, USA

Abstract

HSV-1 ICP0 is a multifunctional immediate early protein key to effective replication in the HSV-1 lytic cycle and reactivation in the latent cycle. ICP0 transactivates gene expression by orchestrating an overall mitigation in host intrinsic/innate restrictions. How ICP0 coordinates its multiple active domains and its diverse protein-protein interactions is a key question in understanding the HSV-1 life cycle and pathogenesis. The present study focuses on delineating the regulatory effects of the SUMO-SIM interaction on ICP0 E3 ubiquitin ligase activity regarding PML II degradation. For the first time, we discovered the importance of multivalency in the PML II-ICP0 interaction network and report the involvement of different regulatory mechanisms in PML II recognition by ICP0 in HSV-1 infection.

Funder

HHS | NIH | National Institute of Allergy and Infectious Diseases

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.00470-20

Reference46 articles.

1. Roizman B, Knipe DM, Whitley RJ. 2013. Herpes simplex viruses, p 1823–1897. In Knipe DM, Howley PM, Cohen JI, Griffin DE, Lamb RA, Martin MA, Racaniello VR, Roizman B (ed), Fields virology, 6th ed, vol 2.Lippincott Williams & Wilkins, Philadelphia, PA.

2. Infected cell protein 0 functional domains and their coordination in herpes simplex virus replication

3. Herpes virus induced proteasome-dependent degradation of the nuclear bodies-associated PML and Sp100 proteins

4. Herpes Simplex Virus Type 1 Immediate-Early Protein Vmw110 Induces the Proteasome-Dependent Degradation of the Catalytic Subunit of DNA-Dependent Protein Kinase

5. Nuclear IFI16 induction of IRF-3 signaling during herpesviral infection and degradation of IFI16 by the viral ICP0 protein

Cited by 16 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. HSV‐1 ICP0 dimer domain adopts a novel β‐barrel fold;Proteins: Structure, Function, and Bioinformatics;2024-02-19

2. HSV-1 ICP0 Dimer Domain Adopts a Novel β-barrel Fold;2024-01-16

3. Regulation of SARS-CoV-2 infection and antiviral innate immunity by ubiquitination and ubiquitin-like conjugation;Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms;2023-12

4. Cell Intrinsic Determinants of Alpha Herpesvirus Latency and Pathogenesis in the Nervous System;Viruses;2023-11-22

5. A Novel Recognition by the E3 Ubiquitin Ligase of HSV-1 ICP0 Enhances the Degradation of PML Isoform I to Prevent ND10 Reformation in Late Infection;Viruses;2023-04-27