The Peptidoglycan of Mycobacterium abscessus Is Predominantly Cross-Linked by l , d -Transpeptidases-Reference-Cited by-同舟云学术

The Peptidoglycan of Mycobacterium abscessus Is Predominantly Cross-Linked by l , d -Transpeptidases

Published:2011-02 Issue:3 Volume:193 Page:778-782
ISSN:0021-9193
Container-title:Journal of Bacteriology
language:en
Short-container-title:J Bacteriol

Author:

Lavollay Marie¹²³⁴,Fourgeaud Martine¹²³,Herrmann Jean-Louis⁵,Dubost Lionel⁶⁷,Marie Arul⁶⁷,Gutmann Laurent¹²³⁴,Arthur Michel¹²³,Mainardi Jean-Luc¹²³⁴

Affiliation:

1. INSERM, U872, LRMA, Equipe 12 du Centre de Recherche des Cordeliers, Paris F-75006, France

2. Université Pierre et Marie Curie, UMR S 872, Paris F-75006, France

3. Université Paris Descartes, UMR S 872, Paris F-75006, France

4. Assistance Publique-Hôpitaux de Paris, Hôpital Européen Georges Pompidou, Paris F-75015, France

5. EA3647, Université de Versailles St. Quentin en Yvelines et Service de Microbiologie, Hôpital Raymond Poincaré, AP-HP, Garches, France

6. Muséum National d'Histoire Naturelle, USM0502, Plateforme de Spectrométrie de Masse et de Protéomique du Muséum, Paris F-75005, France

7. CNRS, UMR8041, Paris F-75005, France

Abstract

ABSTRACT Few therapeutic alternatives remain for the treatment of infections due to multiresistant Mycobacterium abscessus . Here we show that the peptidoglycans of the “rough” and “smooth” morphotypes contain predominantly 3→3 cross-links generated by l , d -transpeptidases, indicating that these enzymes are attractive targets for the development of efficient drugs.

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JB.00606-10

Reference21 articles.

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4. Preliminary Characterization of a Mycobacterium abscessus Mutant in Human and Murine Models of Infection

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