Characterization of Pseudomonas aeruginosa <scp>l,d</scp> -Transpeptidases and Evaluation of Their Role in Peptidoglycan Adaptation to Biofilm Growth-Reference-Cited by-同舟云学术

Characterization of Pseudomonas aeruginosa l,d -Transpeptidases and Evaluation of Their Role in Peptidoglycan Adaptation to Biofilm Growth

Published:2023-08-17 Issue:4 Volume:11 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Hugonneau-Beaufet Inès¹,Barnier Jean-Philippe¹²³,Thiriet-Rupert Stanislas⁴,Létoffé Sylvie⁴,Mainardi Jean-Luc¹²³,Ghigo Jean-Marc⁴,Beloin Christophe⁴^ORCID,Arthur Michel¹^ORCID

Affiliation:

1. Centre de Recherche des Cordeliers, Sorbonne Université, INSERM, Université Paris Cité, Paris, France

2. Service de Microbiologie, Hôpital Européen Georges Pompidou, AP-HP Assistance Publique-Hôpitaux de Paris, Paris, France

3. Université Paris Cité, Faculté de Santé, UFR de Médecine, Paris, France

4. Institut Pasteur, Université Paris Cité, UMR CNRS 6047, Genetics of Biofilms Laboratory, Paris, France

Abstract

Active-site cysteine LDTs form a functionally heterologous family of enzymes that contribute to the biogenesis of the bacterial cell envelope through formation of peptidoglycan cross-links and through the dynamic anchoring of lipoproteins to peptidoglycan. Here, we report the role of three P. aeruginosa LDTs that had not been previously characterized.

Funder

Agence Nationale de la Recherche

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.05217-22

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