Efficacy of Caspofungin against Aspergillus flavus , Aspergillus terreus , and Aspergillus nidulans-Reference-Cited by-同舟云学术

Efficacy of Caspofungin against Aspergillus flavus , Aspergillus terreus , and Aspergillus nidulans

Published:2006-12 Issue:12 Volume:50 Page:4202-4205
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Bowman J. C.¹,Abruzzo G. K.¹,Flattery A. M.¹,Gill C. J.¹,Hickey E. J.¹,Hsu M. J.¹,Nielsen Kahn J.¹,Liberator P. A.¹,Misura A. S.¹,Pelak B. A.¹,Wang T. C.²,Douglas C. M.¹

Affiliation:

1. Departments of Infectious Disease

2. Biometrics Research, Merck Research Laboratories, Rahway, NJ 07065-0900

Abstract

ABSTRACT The echinocandin caspofungin is a potent inhibitor of the activity of 1,3-β- d -glucan synthase from Aspergillus flavus , Aspergillus terreus , and Aspergillus nidulans . In murine models of disseminated infection, caspofungin prolonged survival and reduced the kidney fungal burden. Caspofungin was at least as effective as amphotericin B against these filamentous fungi in vivo.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.00485-06

Reference31 articles.

1. Efficacy of the Echinocandin Caspofungin against Disseminated Aspergillosis and Candidiasis in Cyclophosphamide-Induced Immunosuppressed Mice

2. Gapped BLAST and PSI-BLAST: a new generation of protein database search programs

3. In Vitro Susceptibility Testing Methods for Caspofungin against Aspergillus and Fusarium Isolates

4. Efficacy of Caspofungin against Aspergillus terreus

5. Quantitative PCR Assay To Measure Aspergillus fumigatus Burden in a Murine Model of Disseminated Aspergillosis: Demonstration of Efficacy of Caspofungin Acetate

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