Is there a paradigm shift in use of microsomes and hepatocytes in drug discovery and development?-Reference-Cited by-同舟云学术

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Is there a paradigm shift in use of microsomes and hepatocytes in drug discovery and development?

Published:2016-06-29 Issue:2 Volume:4 Page:114
ISSN:1848-7718
Container-title:ADMET and DMPK
language:
Short-container-title:ADMET DMPK

Author:

Basu Sumit,Shaik Abdul Naveed^ORCID

Abstract

Opinion

Publisher

International Association of Physical Chemists (IAPC)

Subject

Pharmacology (medical),General Pharmacology, Toxicology and Pharmaceutics,Chemistry (miscellaneous),Medicine (miscellaneous)

Link

http://pub.iapchem.org/ojs/index.php/admet/article/viewFile/317/pdf

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1. Identification of the metabolite of ophiopogonanone A by liquid chromatography/quadrupole time‐of‐flight mass spectrometry;Rapid Communications in Mass Spectrometry;2022-04-19

2. Characterization of the metabolites of tirabrutinib generated from rat, dog and human liver microsomes using ultra‐high‐performance liquid chromatography combined with high‐resolution mass spectrometry;Rapid Communications in Mass Spectrometry;2022-01-18

3. In vitro metabolic profiles of motolimod by using liquid chromatography tandem mass spectrometry: Metabolic stability, metabolite characterization and species comparison;Journal of Pharmaceutical and Biomedical Analysis;2019-04

4. CYP enzymes, expressed within live human suspension cells, are superior to widely-used microsomal enzymes in identifying potent CYP1A1/CYP1B1 inhibitors: Identification of quinazolinones as CYP1A1/CYP1B1 inhibitors that efficiently reverse B[a]P toxicity and cisplatin resistance;European Journal of Pharmaceutical Sciences;2019-04

5. Physiologically based pharmacokinetic (PBPK) modeling and simulation in drug discovery and development;ADMET and DMPK;2019-02-23

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