Characterization of the metabolites of tirabrutinib generated from rat, dog and human liver microsomes using ultra‐high‐performance liquid chromatography combined with high‐resolution mass spectrometry-Reference-Cited by-同舟云学术

Characterization of the metabolites of tirabrutinib generated from rat, dog and human liver microsomes using ultra‐high‐performance liquid chromatography combined with high‐resolution mass spectrometry

Published:2022-01-18 Issue:5 Volume:36 Page:
ISSN:0951-4198
Container-title:Rapid Communications in Mass Spectrometry
language:en
Short-container-title:Rapid Comm Mass Spectrometry

Author:

Zhang Hongjian¹²,Hu Zhen³,Zhang Huiping¹²,Sun Xiyan¹²,Yang Jianming⁴^ORCID,Yuan Jie⁵

Affiliation:

1. Department of Otorhinolaryngology‐Head and Neck Surgery, Hefei Cancer Hospital Chinese Academy of Science Hefei China

2. Anhui Province Key Laboratory of Medical Physics and Technology, Institute of Health & Medical Technology, Hefei Institutes of Physical Science Chinese Academy of Sciences Hefei China

3. Department of Radiology The Second Hospital of Anhui Medical University Hefei China

4. Department of Otorhinolaryngology‐Head and Neck Surgery The Second Hospital of Anhui Medical University Hefei China

5. Anhui Provincial Institute for Food and Drug Control Hefei China

Publisher

Wiley

Subject

Organic Chemistry,Spectroscopy,Analytical Chemistry

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/rcm.9240

Reference14 articles.

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3. A phase 1 clinical trial of the selective BTK inhibitor ONO/GS‐4059 in relapsed and refractory mature B‐cell malignancies;Walter HS;Blood,2016

4. Phase I study of tirabrutinib (ONO‐4059/GS‐4059) in patients with relapsed or refractory B‐cell malignancies in Japan;Munakata W;Cancer Sci,2019

5. Species differences between mouse, rat, dog, monkey and human CYP‐mediated drug metabolism, inhibition and induction;Martignoni M;Expert Opin Drug Metab Toxicol,2006

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