CYP enzymes, expressed within live human suspension cells, are superior to widely-used microsomal enzymes in identifying potent CYP1A1/CYP1B1 inhibitors: Identification of quinazolinones as CYP1A1/CYP1B1 inhibitors that efficiently reverse B[a]P toxicity and cisplatin resistance

Author:

Sonawane Vinay R.,Siddique Mohd Usman Mohd,Gatchie Linda,Williams Ibidapo S.,Bharate Sandip B.,Jayaprakash Venkatesan,Sinha Barij N.,Chaudhuri Bhabatosh

Funder

UKIERI

HEIF-UK

CYP-Design Ltd

Publisher

Elsevier BV

Subject

Pharmaceutical Science

Reference69 articles.

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2. Cytochrome P450 CYP1A1: wider roles in cancer progression and prevention;Androutsopoulos;BMC Cancer,2009

3. Is there a paradigm shift in use of microsomes and hepatocytes in drug discovery and development?;Basu;ADMET & DMPK,2016

4. Cancer biology and hormesis: human tumor cell lines commonly display hormetic (biphasic) dose responses;Calabrese;Crit. Rev. Toxicol.,2005

5. Inhibitory activity of the human cytochrome P450 and in vitro cytotoxic effects on human hepatocytes of Nefazodone, Triazoledione, M-chlorophenylpiperazine and Trazodone.;Capezzone de Joannon;Pharmacol. Online,2005

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