Hemodynamic differences caused by left atrial appendage modeling contours

Author:

Chen YanluORCID,Xu Buyun,Cheng Yuzhou,Luo KunORCID,Fan Jianren,Xiang Meixiang

Abstract

Comparing the hemodynamic parameters of thrombus-positive and thrombus-negative patients in the early stages of the disease (before thrombus formation occurs) can help predict atrial fibrillation-related thrombosis. However, most clinical images of thrombus-positive are of existing thrombus, and the presence of thrombi blurs the outline of the atrial appendage intima. Therefore, using the left atrial appendage (LAA) epicardial geometry for hemodynamic analysis has become a last resort. This study compares hemodynamic differences using the modeling contour of the inner and outer membranes of the LAA. The research results show the velocity and shear strain rate of the endocardial and epicardial geometries exhibit relative consistency. As for the parameters related to wall shear stress, the difference in time-averaged wall shear stress mainly occurs at the LAA entrance and does not affect the determination of thrombosis risk factors. The difference in the oscillatory shear index mainly occurs at the tip of LAA and the parts with larger curvature, which are seriously affected by geometry. The differences between endothelial cell activation potential (ECAP) and relative residence time (RRT) are concentrated at the tip of the LAA, but the maximum and minimum values are significantly different. After we exclude the top and bottom 5% of values, we believe that ECAP and RRT are reliable parameters. This investigation conducted both qualitative and quantitative assessments of the hemodynamic disparities between the endocardial and epicardial geometries. The findings offer valuable data reference for related research.

Funder

National Natural Science Foundation of China

Publisher

AIP Publishing

Subject

Condensed Matter Physics,Fluid Flow and Transfer Processes,Mechanics of Materials,Computational Mechanics,Mechanical Engineering

Cited by 3 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3