The impact of left atrial morphology on thrombosis risk in atrial fibrillation

Author:

Wang YanORCID,Xu Buyun,Luo KunORCID,Fan JianrenORCID,Xiang Meixiang

Abstract

Atrial fibrillation (AF) is an arrhythmia disease that can disrupt the movement of the left atrium (LA), which will facilitate thromboembolism in LA and further exacerbate the stroke risk. The left atrial appendage (LAA) is a vital site for thrombus formation. The morphology of the LAA is believed to have a profound effect on thrombosis. However, due to the limitation of observation and monitoring methods, the mechanism of this effect is still unrevealed. Virchow's triad is a theory of thrombogenic mechanisms, stating that endothelial injury, blood hypercoagulability, and blood stasis are the three main factors involved in thrombus formation. In this study, we conducted personalized simulation analyses for 12 AF patients and discussed simulation results from the perspective of Virchow's triad. The simulation results indicate the effectiveness of Virchow's triad in elucidating the thrombosis mechanism within the LAA. The LAA is more prone to thrombosis than the other region of LA, because of the lower blood flow velocity and significantly higher endothelial cell activation potential values there, which indicates a higher risk of blood stasis and endothelial injury, respectively. Furthermore, a comprehensive score is proposed to assess the performance of Virchow's triad in the LAA. The morphology of LA has a significant influence on the performance of the three factors in Virchow's triad. Hence, for a quickly assessment of LAA thrombosis risk in AF patients through the lens of Virchow's triad, we need a more refined shape scoring system that can better reflect patient-specific morphological features of the entire LA.

Funder

National Natural Science Foundation of China

Publisher

AIP Publishing

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3