Asparagus adscendens(Shweta musali) stimulates insulin secretion, insulin action and inhibits starch digestion

Abstract

Diabetes mellitus is a complex metabolic disease characterised by glucose overproduction and under-utilisation. As the incidence of diabetes expands rapidly across the globe there is an urgent need to expand the range of effective treatments. Higher plants such asAsparagus adscendensprovide therapeutic opportunities and a rich source of potential antidiabetic agents. In the present study an aqueous extract ofAsparagus adscendenswas shown to induce a significant non-toxic 19–248% increase in glucose-dependent insulinotropic actions (P<0·001) in the clonal pancreatic β cell line, BRIN-BD11. In addition, the extract produced an 81% (P<0·0001) increase in glucose uptake in 3T3-L1 adipocytes.Asparagus adscendensalso produced a 21% (P<0·001) decrease in starch digestionin vitro. The present study has revealed the presence of insulinotropic, insulin-enhancing activity and inhibitory effects on starch digestion inAsparagus adscendens. The former actions are dependent on the active principle(s) in the plant being absorbed intact. Future work assessing its use as a dietary adjunct or as a source of active components may provide new opportunities for the treatment of diabetes