Author:
Enciu Ana M,Nicolescu Mihnea I,Manole Catalin G,Mureşanu Dafin F,Popescu Laurenţiu M,Popescu Bogdan O
Abstract
Abstract
Background
Neuroregeneration is a relatively recent concept that includes neurogenesis, neuroplasticity, and neurorestoration - implantation of viable cells as a therapeutical approach.
Discussion
Neurogenesis and neuroplasticity are impaired in brains of patients suffering from Alzheimer's Disease or Parkinson's Disease and correlate with low endogenous protection, as a result of a diminished growth factors expression. However, we hypothesize that the brain possesses, at least in early and medium stages of disease, a "neuroregenerative reserve", that could be exploited by growth factors or stem cells-neurorestoration therapies.
Summary
In this paper we review the current data regarding all three aspects of neuroregeneration in Alzheimer's Disease and Parkinson's Disease.
Publisher
Springer Science and Business Media LLC
Subject
Clinical Neurology,General Medicine
Cited by
77 articles.
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