Abstract
AbstractN6-methyladenosine (m6A) modification has been shown to regulate RNA metabolism. Here, we investigate m6A dynamics during maternal-to-zygotic transition (MZT) in mice through multi-omic analysis. Our results show that m6A can be maternally inherited or de novo gained after fertilization. Interestingly, m6A modification on maternal mRNAs not only correlates with mRNA degradation, but also maintains the stability of a small group of mRNAs thereby promoting their translation after fertilization. We identify Ythdc1 and Ythdf2 as key m6A readers for mouse preimplantation development. Our study reveals a key role of m6A mediated RNA metabolism during MZT in mammals.
Funder
Shanghai Municipal Science and Technology Commission technical standard project
Shanghai Municipal Science and Technology Major Project
Strategic Priority Research Program of the Chinese Academy of Sciences
Basic Frontier Scientific Research Program of CAS
Shanghai Municipal Science and Technology Commission natural science foundation project
the innovative research team of high-level local universities in Shanghai
the Yangfan Project of Shanghai Science and Technology Commission
China Postdoctoral Science Foundation
Publisher
Springer Science and Business Media LLC
Cited by
4 articles.
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