Metabolic profiles of coumarin in human plasma extrapolated from a rat data set with a simplified physiologically based pharmacokinetic model
Author:
Affiliation:
1. Showa Pharmaceutical University
Publisher
Japanese Society of Toxicology
Subject
Toxicology
Link
https://www.jstage.jst.go.jp/article/jts/45/11/45_695/_pdf
Reference26 articles.
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2. Born, S.L., Caudill, D., Fliter, K.L. and Purdon, M.P. (2002): Identification of the cytochromes P450 that catalyze coumarin 3,4-epoxidation and 3-hydroxylation. Drug Metab. Dispos., 30, 483-487.
3. Born, S.L., Caudill, D., Smith, B.J. and Lehman-McKeeman, L.D. (2000): In vitro kinetics of coumarin 3,4-epoxidation: application to species differences in toxicity and carcinogenicity. Toxicol. Sci., 58, 23-31.
4. Kamiya, Y., Otsuka, S., Miura, T., Takaku, H., Yamada, R., Nakazato, M., Nakamura, H., Mizuno, S., Shono, F., Funatsu, K. and Yamazaki, H. (2019): Plasma and hepatic concentrations of chemicals after virtual oral administrations extrapolated using rat plasma data and simple physiologically based pharmacokinetic models. Chem. Res. Toxicol., 32, 211-218.
5. Kamiya, Y., Otsuka, S., Miura, T., Yoshizawa, M., Nakano, A., Iwasaki, M., Kobayashi, Y., Shimizu, M., Kitajima, M., Shono, F., Funatsu, K. and Yamazaki, H. (2020a): Physiologically based pharmacokinetic models predicting renal and hepatic concentrations of industrial chemicals after virtual oral doses in rats. Chem. Res. Toxicol., 33, 1736-1751.
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