Physiologically Based Pharmacokinetic Models Predicting Renal and Hepatic Concentrations of Industrial Chemicals after Virtual Oral Doses in Rats

Author:

Kamiya Yusuke1,Otsuka Shohei1,Miura Tomonori1,Yoshizawa Manae1,Nakano Ayane1,Iwasaki Miyu1,Kobayashi Yui1,Shimizu Makiko1,Kitajima Masato2,Shono Fumiaki3,Funatsu Kimito3ORCID,Yamazaki Hiroshi1ORCID

Affiliation:

1. Laboratory of Drug Metabolism and Pharmacokinetics, Showa Pharmaceutical University, 3-3165 Higashi-tamagawa Gakuen, Machida, Tokyo 194-8543, Japan

2. Fujitsu Kyusyu Systems, Higashi-hie, Hakata-ku, Fukuoka 812-0007, Japan

3. Department of Chemical System Engineering, School of Engineering, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113-8656, Japan

Funder

Ministry of Economy, Trade and Industry

Japan Society for the Promotion of Science

Publisher

American Chemical Society (ACS)

Subject

Toxicology,General Medicine

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