Perspective of Humanized Mouse Models for Assessing PK/PD and Toxic Profile of Drug Candidates in Preclinical Study
Author:
Publisher
Japanese Society for the Study of Xenobiotics
Subject
Pharmacology (medical),Pharmaceutical Science,Pharmacology
Reference11 articles.
1. Humanized mouse lines and their application for prediction of human drug metabolism and toxicological risk assessment;Cheung;J. Pharmacol. Exp. Ther.,2008
2. Generation and utility of genetically humanized mouse models;Scheer;Drug Discov. Today,2013
3. Transchromosomic mice containing a human CYP3A cluster for prediction of xenobiotic metabolism in humans;Kazuki;Hum. Mol. Genet.,2013
4. Quantitative prediction of human pregnane X receptor and cytochrome P450 3A4 mediated drug-drug interaction in a novel multiple humanized mouse line;Hasegawa;Mol. Pharmacol.,2011
5. Kitamura, S. and Sugihara, K.: Current status of prediction of drug disposition and toxicity in humans using chimeric mice with humanized liver. Xenobiotica, in press.
Cited by 25 articles. 订阅此论文施引文献 订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献
1. Study on the therapeutic material basis and effect of Acanthopanax senticosus (Rupr. et Maxim.) Harms leaves in the treatment of ischemic stroke by PK-PD analysis based on online microdialysis–LC-MS/MS method;Food & Function;2020
2. HIV‐protease inhibitors for the treatment of cancer: Repositioning HIV protease inhibitors while developing more potent NO‐hybridized derivatives?;International Journal of Cancer;2017-01-20
3. Integrated Lead Optimization: Translational Models as We Advance Toward the Clinic;Translating Molecules into Medicines;2017
4. Use of Chemical Auxiliaries to Control P450 Enzymes for Predictable Oxidations at Unactivated C-H Bonds of Substrates;Advances in Experimental Medicine and Biology;2015
5. Abiraterone inhibits 1α,25-dihydroxyvitamin D3 metabolism by CYP3A4 in human liver and intestine in vitro;The Journal of Steroid Biochemistry and Molecular Biology;2014-10
1.学者识别学者识别
2.学术分析学术分析
3.人才评估人才评估
"同舟云学术"是以全球学者为主线，采集、加工和组织学术论文而形成的新型学术文献查询和分析系统，可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容，当前同舟云学术共收录了国内外主流学术期刊6万余种，收集的期刊论文及会议论文总量共计约1.5亿篇，并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询！咨询电话：010-8811{复制后删除}0370
www.globalauthorid.com
TOP
Copyright © 2019-2024 北京同舟云网络信息技术有限公司 京公网安备11010802033243号 京ICP备18003416号-3