Study on the therapeutic material basis and effect of Acanthopanax senticosus (Rupr. et Maxim.) Harms leaves in the treatment of ischemic stroke by PK-PD analysis based on online microdialysis

Study on the therapeutic material basis and effect of Acanthopanax senticosus (Rupr. et Maxim.) Harms leaves in the treatment of ischemic stroke by PK-PD analysis based on online microdialysis–LC-MS/MS method

Published:2020 Issue:3 Volume:11 Page:2005-2016
ISSN:2042-6496
Container-title:Food & Function
language:en
Short-container-title:Food Funct.

Author:

Wang Yu¹²³⁴⁵,Liu Shu⁵⁶⁷⁸⁴^ORCID,Wang Rongjin¹²³⁴,Shi Liqiang¹²³⁴,Liu Zhiqiang⁵⁶⁷⁸⁴,Liu Zhongying¹²³⁴^ORCID

Affiliation:

1. School of Pharmaceutical Sciences

2. Jilin University

3. Changchun 130021

4. China

5. National Center of Mass Spectrometry in Changchun & Jilin Provincial Key Laboratory of Chinese Medicine Chemistry and Mass Spectrometry

6. Changchun Institute of Applied Chemistry

7. Chinese Academy of Sciences

8. Changchun

Abstract

The therapeutic material basis and effect of ASL in the treatment of ischemic stroke were studied by PK-PD analysis.

Funder

National Natural Science Foundation of China

Jilin Scientific and Technological Development Program

Publisher

Royal Society of Chemistry (RSC)

Subject

General Medicine,Food Science

Link

http://pubs.rsc.org/en/content/articlepdf/2020/FO/C9FO02475A

Reference30 articles.

1. Systematic studies on the in vivo substance basis and the pharmacological mechanism of Acanthopanax Senticosus Harms leaves by UPLC-Q-TOF-MS coupled with a target-network method

2. Pharmacokinetic Study of Biotransformation Products from an Anxiolytic Fraction of Tilia americana

3. Effects of Acanthopanax senticosus on Brain Injury Induced by Simulated Spatial Radiation in Mouse Model Based on Pharmacokinetics and Comparative Proteomics

4. Screening and Determination for Potential α-Glucosidase Inhibitors from Leaves of Acanthopanax senticosus Harms by Using UF-LC/MS and ESI-MSn

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