Carotid Bodies and the Integrated Cardiorespiratory Response to Hypoxia

Author:

Lindsey Bruce G.1,Nuding Sarah C.1,Segers Lauren S.1,Morris Kendall F.1

Affiliation:

1. Department of Molecular Pharmacology and Physiology, Morsani College of Medicine, University of South Florida, Tampa, Florida

Abstract

Advances in our understanding of brain mechanisms for the hypoxic ventilatory response, coordinated changes in blood pressure, and the long-term consequences of chronic intermittent hypoxia as in sleep apnea, such as hypertension and heart failure, are giving impetus to the search for therapies to “erase” dysfunctional memories distributed in the carotid bodies and central nervous system. We review current network models, open questions, sex differences, and implications for translational research.

Funder

HHS | NIH | National Institute of Neurological Disorders and Stroke (NINDS)

Publisher

American Physiological Society

Subject

Physiology

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