Activity-Dependent Signaling Pathways Controlling Muscle Diversity and Plasticity

Author:

Schiaffino Stefano123,Sandri Marco134,Murgia Marta1

Affiliation:

1. Department of Biomedical Sciences, University of Padova,

2. Consiglio Nazionale delle Ricerche (CNR) Institute of Neurosciences,

3. Venetian Institute of Molecular Medicine (VIMM), and

4. Dulbecco Telethon Institute, Padova, Italy

Abstract

A variety of fiber types with different contractile and metabolic properties is present in mammalian skeletal muscle. The fiber-type profile is controlled by nerve activity via specific signaling pathways, whose identification may provide potential therapeutic targets for the prevention and treatment of metabolic and neuromuscular diseases.

Publisher

American Physiological Society

Subject

Physiology

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