Affiliation:
1. Department of Pharmacology and Physiology, University of Rochester Medical Center, Rochester, New York 14642
Abstract
In many nonexcitable cells, stimulation with low agonist concentrations specifically activates Ca2+entry via arachidonic acid-regulated, highly Ca2+-selective ARC channels. Only at high agonist concentrations are the more widely studied store-operated channels activated, producing sustained elevated cytosolic Ca2+concentration signals. These signals activate calcineurin, which in turn inhibits the ARC channels, resulting in a “reciprocal regulation” of these two distinct Ca2+-entry pathways that may have important functional implications for the cell.
Publisher
American Physiological Society
Cited by
76 articles.
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