Astrocytes Function in Matching Blood Flow to Metabolic Activity-Reference-Cited by-同舟云学术

Astrocytes Function in Matching Blood Flow to Metabolic Activity

Published:2002-02 Issue:1 Volume:17 Page:27-31
ISSN:1548-9213
Container-title:Physiology
language:en
Short-container-title:Physiology

Author:

Harder David R.¹²,Zhang Chenyang¹,Gebremedhin Debebe¹

Affiliation:

1. Department of Physiology and Cardiovascular Research Center, Medical College of Wisconsin, and

2. Zablocki Veterans Affairs Medical Center, Milwaukee, Wisconsin 53226

Abstract

The brain possesses an intrinsic regulatory mechanism to maintain an adequate supply of O2 and nutrition despite local increases in neuronal activity. Brain astrocytes function as an intermediary cell type by responding to glutamate released from activated neurons, and they couple cerebral blood flow by producing cytochrome P-450-derived epoxyeicosatrienoic acids that induce vasodilation and increase capillary density.

Publisher

American Physiological Society

Subject

Physiology

Link

https://www.physiology.org/doi/pdf/10.1152/physiologyonline.2002.17.1.27

Reference15 articles.

1. Inhibition of brain P-450 arachidonic acid epoxygenase decreases baseline cerebral blood flow

2. P-450 epoxygenase and NO synthase inhibitors reduce cerebral blood flow response toN-methyl-d-aspartate

3. Leptin, the Product of Ob Gene, Promotes Angiogenesis

4. Epoxyeicosatrienoic Acids and Their Sulfonimide Derivatives Stimulate Tyrosine Phosphorylation and Induce Mitogenesis in Renal Epithelial Cells

5. Continuous Measurement of Cerebral Cortical Blood Flow by Laser—Doppler Flowmetry in a Rat Stroke Model

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