Relationship of circulating levels of long-chain fatty acids to persistent organ failure in acute pancreatitis-Reference-Cited by-同舟云学术

Relationship of circulating levels of long-chain fatty acids to persistent organ failure in acute pancreatitis

Published:2023-09-01 Issue:3 Volume:325 Page:G279-G285
ISSN:0193-1857
Container-title:American Journal of Physiology-Gastrointestinal and Liver Physiology
language:en
Short-container-title:American Journal of Physiology-Gastrointestinal and Liver Physiology

Author:

Phillips Anna Evans¹^ORCID,Wilson Annette S.¹,Greer Phil J.¹,Hinton Alice²,Culp Stacey³,Paragomi Pedram¹,Pothoulakis Ioannis¹,Singh Vijay⁴,Lee Peter J.⁵,Lahooti Ila⁵,Whitcomb David C.¹^ORCID,Papachristou Georgios I.⁵

Affiliation:

1. Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States

2. Division of Biostatistics, College of Public Health, The Ohio State University, Columbus, Ohio, United States

3. Department of Biomedical Informatics, College of Medicine, The Ohio State University, Columbus, Ohio, United States

4. Division of Gastroenterology, Department of Medicine, Mayo Clinic, Scottsdale, Arizona, United States

5. Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, The Ohio State University, Columbus, Ohio, United States

Abstract

Drivers of the inflammatory response in acute pancreatitis remain incompletely understood. Unsaturated fatty acids, specifically palmitoleic, appear to have an association with more severe acute pancreatitis. This finding presents a new clinical understanding of fatty acid toxicity and highlights a potential future target for treatment in severe acute pancreatitis.

Funder

HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases

U.S. Department of Defense

Publisher

American Physiological Society

Subject

Physiology (medical),Gastroenterology,Hepatology,Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpgi.00074.2023

Reference41 articles.

1. Organ Failure Due to Systemic Injury in Acute Pancreatitis

2. Physiological parameters governing the action of pancreatic lipase