Differences in Plasma Fatty Acid Composition Related to Chronic Pancreatitis

Author:

Gumpper-Fedus Kristyn,Crowe Olivia1,Hart Phil A.,Pita-Grisanti Valentina,Velez-Bonet Ericka,Belury Martha A.2,L. Ramsey Mitchell3,Cole Rachel M.2,Badi Niharika,Culp Stacey4,Hinton Alice5,F. Lara Luis6,Krishna Somashekar G.,Conwell Darwin L.7,Cruz-Monserrate Zobeida

Affiliation:

1. The Ohio State University College of Medicine

2. Department of Food Science and Technology, College of Food, Agriculture, and Environmental Sciences, The Ohio State University

3. Division of Gastroenterology, Hepatology, and Nutrition, Department of Internal Medicine

4. Department of Biomedical Informatics

5. Division of Biostatistics, College of Public Heath, The Ohio State University Wexner Medical Center, Columbus

6. Department of Internal Medicine, Division of Digestive Diseases, University of Cincinnati College of Medicine, Cincinnati, OH

7. Department of Internal Medicine, University of Kentucky College of Medicine, Lexington, KY.

Abstract

Objectives Chronic pancreatitis (CP) is an inflammatory disease affecting the absorption of fat-soluble nutrients. Signaling in pancreatic cells that lead to inflammation may be influenced by fatty acids (FAs) through diet and de novo lipogenesis. Here, we investigated the relationship between plasma FA composition in CP with heterogeneity of etiology and complications of CP. Materials and Methods Blood and clinical parameters were collected from subjects with CP (n = 47) and controls (n = 22). Plasma was analyzed for FA composition using gas chromatography and compared between controls and CP and within CP. Results Palmitic acid increased, and linoleic acid decreased in CP compared with controls. Correlations between age or body mass index and FAs are altered in CP compared with controls. Diabetes, pancreatic calcifications, and substance usage, but not exocrine pancreatic dysfunction, were associated with differences in oleic acid and linoleic acid relative abundance in CP. De novo lipogenesis index was increased in the plasma of subjects with CP compared with controls and in calcific CP compared with noncalcific CP. Conclusions Fatty acids that are markers of de novo lipogenesis and linoleic acid are dysregulated in CP depending on the etiology or complication. These results enhance our understanding of CP and highlight potential pathways targeting FAs for treating CP.

Publisher

Ovid Technologies (Wolters Kluwer Health)

Reference54 articles.

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4. Chronic pancreatitis and pancreatic cancer risk: a systematic review and meta-analysis;Am J Gastroenterol,2017

5. Early detection of pancreatic cancer;Lancet Gastroenterol Hepatol,2020

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