Lipotoxicity Causes Multisystem Organ Failure and Exacerbates Acute Pancreatitis in Obesity-Reference-Cited by-同舟云学术

Lipotoxicity Causes Multisystem Organ Failure and Exacerbates Acute Pancreatitis in Obesity

Published:2011-11-02 Issue:107 Volume:3 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Navina Sarah¹,Acharya Chathur²,DeLany James P.³,Orlichenko Lidiya S.³,Baty Catherine J.⁴,Shiva Sruti S.⁵,Durgampudi Chandra²,Karlsson Jenny M.⁴,Lee Kenneth⁶,Bae Kyongtae T.⁷,Furlan Alessandro⁷,Behari Jaideep³,Liu Shiguang³,McHale Teresa¹,Nichols Larry¹,Papachristou Georgios Ioannis³,Yadav Dhiraj³,Singh Vijay P.³

Affiliation:

1. Department of Pathology, University of Pittsburgh, 200 Lothrop Street, Pittsburgh, PA 15213, USA.

2. Department of Medicine, University of Pittsburgh Medical Center, McKeesport, PA 15132, USA.

3. Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA.

4. Department of Cell Biology and Physiology, University of Pittsburgh, Pittsburgh, PA 15213, USA.

5. Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, PA 15213, USA.

6. Department of Surgery, University of Pittsburgh, Pittsburgh, PA 15213, USA.

7. Department of Radiology, University of Pittsburgh, Pittsburgh, PA 15213, USA.

Abstract

Unsaturated fatty acids cause lipotoxicity and mediate acute adverse outcomes in obese individuals with pancreatitis.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference89 articles.

1. Body mass index (BMI) and mortality in patients with severe burns: Is there a “tilt point” at which obesity influences outcome?;Ghanem A. M.;Burns,2011

2. Obesity is an independent risk factor of mortality in severely injured blunt trauma patients;Neville A. L.;Arch. Surg.,2004

3. Obesity increases risk of organ failure after severe trauma;Ciesla D. J.;J. Am. Coll. Surg.,2006

4. Obesity and mortality in critically ill adults: A systematic review and meta-analysis;Oliveros H.;Obesity,2008

5. Obesity Increases the Severity of Acute Pancreatitis: Performance of APACHE-O Score and Correlation with the Inflammatory Response

Cited by 337 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Chaiqin chengqi decoction treatment mitigates hypertriglyceridemia-associated acute pancreatitis by modulating liver-mediated glycerophospholipid metabolism;Phytomedicine;2024-11

2. Natural history of spontaneous pancreatic portal vein fistulae: A systematic review of the literature;Pancreatology;2024-09

3. Modeling protease-sensitive human pancreatic lipase mutations in the mouse ortholog;Journal of Biological Chemistry;2024-09

4. Deletion of the WD40 domain of ATG16L1 exacerbates acute pancreatitis, abolishes LAP-like non-canonical autophagy and slows trypsin degradation;Autophagy;2024-08-31

5. Adipose Triglyceride Lipase–Mediated Adipocyte Lipolysis Exacerbates Acute Pancreatitis Severity in Mouse Models and Patients;The American Journal of Pathology;2024-08