Cross-species comparison of pregnancy-induced GDF15-Reference-Cited by-同舟云学术

Cross-species comparison of pregnancy-induced GDF15

Published:2023-10-01 Issue:4 Volume:325 Page:E303-E309
ISSN:0193-1849
Container-title:American Journal of Physiology-Endocrinology and Metabolism
language:en
Short-container-title:American Journal of Physiology-Endocrinology and Metabolism

Author:

Klein Anders Bue¹,Ranea-Robles Pablo¹^ORCID,Nicolaisen Trine Sand¹²,Gil Cláudia¹,Johann Kornelia³⁴,Quesada Júlia Prats⁵,Pistolevij Nina⁵,Hviid Kathrine V.R.⁶⁷,Fich Line⁶⁷,Offersen Simone M.⁸,Helge Jørn Wulff⁵^ORCID,Nielsen Henriette Svarre⁹⁶⁷,Bakker Jaco¹⁰^ORCID,Kleinert Maximilian²³⁴,Clemmensen Christoffer¹^ORCID

Affiliation:

1. Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark

2. Section of Molecular Physiology, Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen, Copenhagen, Denmark

3. German Center for Diabetes Research (DZD), München-Neuherberg, Germany

4. Muscle Physiology and Metabolism Group, German Institute of Human Nutrition (DIfE), Potsdam-Rehbrücke, Nuthetal, Germany

5. Xlab, Center for Healthy Aging, Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark

6. Department of Obstetrics and Gynaecology, Fertility Clinic, Copenhagen University Hospital Hvidovre, Hvidovre, Denmark

7. Institute of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark

8. Section for Comparative Pediatrics and Nutrition, Department of Veterinary and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Frederiksberg, Denmark

9. Fertility Department, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark

10. Animal Science Department, Biomedical Primate Research Centre, Rijswijk, The Netherlands

Abstract

In the present study pregnancy-induced changes in circulating growth differentiation factor 15 (GDF15) in rodents, rhesus macaques, and humans are mapped. In sum, it is demonstrated that humans and macaques exhibit a tremendous increase in placental and circulating GDF15 during pregnancy. In contrast, GDF15 is negligibly increased in pregnant mice and rats, questioning a physiological role for GDF15 in pregnancy in rodents.

Funder

Novo Nordisk

Independent Research Fund of Denmark

Publisher

American Physiological Society

Subject

Physiology (medical),Physiology,Endocrinology, Diabetes and Metabolism

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpendo.00134.2023

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