GFRAL is the receptor for GDF15 and is required for the anti-obesity effects of the ligand-Reference-Cited by-同舟云学术

GFRAL is the receptor for GDF15 and is required for the anti-obesity effects of the ligand

Published:2017-08-28 Issue:10 Volume:23 Page:1158-1166
ISSN:1078-8956
Container-title:Nature Medicine
language:en
Short-container-title:Nat Med

Author:

Yang Linda,Chang Chih-Chuan^ORCID,Sun Zhe,Madsen Dennis,Zhu Haisun^ORCID,Padkjær Søren B,Wu Xiaoai,Huang Tao,Hultman Karin,Paulsen Sarah J,Wang Jishu,Bugge Anne^ORCID,Frantzen Jane Boesen,Nørgaard Per,Jeppesen Jacob Fuglsbjerg,Yang Zhiru,Secher Anna,Chen Haibin^ORCID,Li Xun,John Linu Mary,Shan Bing,He Zhenhua,Gao Xiang^ORCID,Su Jing,Hansen Kristian T,Yang Wei,Jørgensen Sebastian Beck^ORCID

Publisher

Springer Science and Business Media LLC

Subject

General Biochemistry, Genetics and Molecular Biology,General Medicine

Link

http://www.nature.com/articles/nm.4394.pdf

Reference34 articles.

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2. Macia, L. et al. Macrophage inhibitory cytokine 1 (MIC-1/GDF15) decreases food intake, body weight and improves glucose tolerance in mice on normal & obesogenic diets. PLoS One 7, e34868 (2012).

3. Chrysovergis, K. et al. NAG-1/GDF-15 prevents obesity by increasing thermogenesis, lipolysis and oxidative metabolism. Int. J. Obes. 38, 1555–1564 (2014).

4. Tsai, V.W. et al. Serum levels of human MIC-1/GDF15 vary in a diurnal pattern, do not display a profile suggestive of a satiety factor and are related to BMI. PLoS One 10, e0133362 (2015).

5. Tsai, V.W. et al. The anorectic actions of the TGFβ cytokine MIC-1/GDF15 require an intact brainstem area postrema and nucleus of the solitary tract. PLoS One 9, e100370 (2014).

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