Long-acting MIC-1/GDF15 molecules to treat obesity: Evidence from mice to monkeys-Reference-Cited by-同舟云学术

Long-acting MIC-1/GDF15 molecules to treat obesity: Evidence from mice to monkeys

Published:2017-10-18 Issue:412 Volume:9 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Xiong Yumei¹^ORCID,Walker Kenneth²^ORCID,Min Xiaoshan³^ORCID,Hale Clarence⁴^ORCID,Tran Thanhvien¹,Komorowski Renee⁴^ORCID,Yang Jerry¹,Davda Jasmine⁵^ORCID,Nuanmanee Noi²^ORCID,Kemp Dao²,Wang Xiaozhen⁶,Liu Hantao⁷,Miller Silke⁷^ORCID,Lee Ki Jeong²,Wang Zhulun²,Véniant Murielle M.⁴^ORCID

Affiliation:

1. Department of Cardiometabolic Disorders, Amgen Inc., 1120 Veterans Boulevard, South San Francisco, CA 94080, USA.

2. Department of Therapeutic Discovery, Amgen Inc., One Amgen Center Drive, Thousand Oaks, CA 91320, USA.

3. Department of Therapeutic Discovery, Amgen Inc., 1120 Veterans Boulevard, South San Francisco, CA 94080, USA.

4. Department of Cardiometabolic Disorders, Amgen Inc., One Amgen Center Drive, Thousand Oaks, CA 91320, USA.

5. Department of Pharmacokinetics and Drug Metabolism, Amgen Inc., 1120 Veterans Boulevard, South San Francisco, CA 94080, USA.

6. Department of Medical Sciences, Amgen Inc., 1120 Veterans Boulevard, South San Francisco, CA 94080, USA.

7. Department of Neuroscience, Amgen Inc., One Amgen Center Drive, Thousand Oaks, CA 91320, USA.

Abstract

Engineered long-acting GDF15-Fc fusion molecules reduce food intake and body weight and improve metabolic profiles in animal models of obesity.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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2. Weight Loss in Severely Obese Subjects Prevents the Progression of Impaired Glucose Tolerance to Type II Diabetes: A longitudinal interventional study

3. The pharmaceutical market for obesity therapies

4. MIC-1, a novel macrophage inhibitory cytokine, is a divergent member of the TGF- superfamily

5. PLAB, a novel placental bone morphogenetic protein

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