Postexercise changes in myocellular lipid droplet characteristics of young lean individuals are affected by circulatory nonesterified fatty acids-Reference-Cited by-同舟云学术

Postexercise changes in myocellular lipid droplet characteristics of young lean individuals are affected by circulatory nonesterified fatty acids

Published:2021-10-01 Issue:4 Volume:321 Page:E453-E463
ISSN:0193-1849
Container-title:American Journal of Physiology-Endocrinology and Metabolism
language:en
Short-container-title:American Journal of Physiology-Endocrinology and Metabolism

Author:

Daemen Sabine¹,van Polanen Nynke¹^ORCID,Bilet Lena¹,Phielix Esther¹^ORCID,Moonen-Kornips Esther¹,Schrauwen-Hinderling Vera B.¹²,Schrauwen Patrick¹,Hesselink Matthijs K. C.¹^ORCID

Affiliation:

1. Department of Nutrition and Movement Sciences, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Centre+, Maastricht, The Netherlands

2. Department of Radiology, Maastricht University Medical Center+, Maastricht, The Netherlands

Abstract

Skeletal muscle stores lipids in lipid droplets (LDs) that can vary in size, number, and location and are a source of energy during exercise. Specifically, subsarcolemmal LDs were used during exercise when fasted. Exercising in the fasted state leads to postrecovery elevation in IMCL levels due to an increase in LD number in type I muscle fibers, in subsarcolemmal region and decorated with PLIN5. These effects are blunted by glucose ingestion during exercise and recovery.

Funder

Diabetes Fonds

EC | European Research Council

Hartstichting

Publisher

American Physiological Society

Subject

Physiology (medical),Physiology,Endocrinology, Diabetes and Metabolism

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpendo.00654.2020

Reference53 articles.

1. Lipid homeostasis, lipotoxicity and the metabolic syndrome