Both moderate- and high-intensity exercise training increase intramyocellular lipid droplet abundance and modify myocellular distribution in adults with obesity-Reference-Cited by-同舟云学术

Both moderate- and high-intensity exercise training increase intramyocellular lipid droplet abundance and modify myocellular distribution in adults with obesity

Published:2023-11-01 Issue:5 Volume:325 Page:E466-E479
ISSN:0193-1849
Container-title:American Journal of Physiology-Endocrinology and Metabolism
language:en
Short-container-title:American Journal of Physiology-Endocrinology and Metabolism

Author:

Schleh Michael W.¹^ORCID,Ahn Cheehoon¹^ORCID,Ryan Benjamin J.¹^ORCID,Chugh Olivia K.¹,Luker Austin T.¹,Luker Kathryn E.²³,Gillen Jenna B.¹⁴^ORCID,Ludzki Alison C.¹^ORCID,Van Pelt Douglas W.¹^ORCID,Pitchford Lisa M.¹,Zhang Tao¹,Rode Thomas¹,Howton Suzette M.¹,Burant Charles F.⁵,Horowitz Jeffrey F.¹^ORCID

Affiliation:

1. Substrate Metabolism Laboratory, School of Kinesiology, University of Michigan, Ann Arbor, Michigan, United States

2. Department of Radiology, Center for Molecular Imaging, University of Michigan, Ann Arbor, Michigan, United States

3. Biointerfaces Institute, University of Michigan, Ann Arbor, Michigan, United States

4. Faculty of Kinesiology and Physical Education, University of Toronto, Toronto, Ontario, Canada

5. Division of Metabolism, Endocrinology, and Diabetes, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, United States

Abstract

In this study, 12 wk of either moderate-intensity continuous training (MICT) or high-intensity interval training (HIIT) enhanced skeletal muscle lipid abundance by increasing lipid droplet number within the intramyofibrillar (IMF) region of muscle. Because the IMF associates with high energy production during muscle contraction, this adaptation may enhance lipid oxidation during exercise. Despite differences in training intensity and energy expenditure between MICT and HIIT, their effects on muscle lipid abundance and metabolism were remarkably similar.

Funder

Gouvernement du Canada | Canadian Institutes of Health Research

HHS | NIH | NIDDK | Division of Diabetes, Endocrinology, and Metabolic Diseases

HHS | NIH | National Cancer Institute

HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases

Publisher

American Physiological Society

Subject

Physiology (medical),Physiology,Endocrinology, Diabetes and Metabolism

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpendo.00093.2023

Reference65 articles.

1. Regulation of endogenous fat and carbohydrate metabolism in relation to exercise intensity and duration

2. Intramyocellular lipids form an important substrate source during moderate intensity exercise in endurance‐trained males in a fasted state

3. Acute exercise increases triglyceride synthesis in skeletal muscle and prevents fatty acid–induced insulin resistance

4. Intramuscular lipid content is increased in obesity and decreased by weight loss

5. Triacylglycerol accumulation in human obesity and type 2 diabetes is associated with increased rates of skeletal muscle fatty acid transport and increased sarcolemmal FAT/CD36