Rapid development of vasopressin resistance in dietary K+ deficiency

Abstract

This study shows that aquaporin-2 regulation is disrupted by a small fall in plasma potassium levels and the response is influenced by sexual dimorphism in renal potassium handling. The findings provided new insights into the mechanisms by which water balance is altered in dietary potassium deficiency and support defining the disorder as “potassium-dependent nephrogenic diabetes insipidus.”