Arginine vasopressin regulates the renal Na+-Cl– and Na+-K+-Cl– cotransporters through with-no-lysine kinase 4 and inhibitor 1 phosphorylation-Reference-Cited by-同舟云学术

Arginine vasopressin regulates the renal Na⁺-Cl^– and Na⁺-K⁺-Cl^– cotransporters through with-no-lysine kinase 4 and inhibitor 1 phosphorylation

Published:2024-02-01 Issue:2 Volume:326 Page:F285-F299
ISSN:1931-857X
Container-title:American Journal of Physiology-Renal Physiology
language:en
Short-container-title:American Journal of Physiology-Renal Physiology

Author:

Carbajal-Contreras Hector¹²,Murillo-de-Ozores Adrian Rafael¹³,Magaña-Avila German¹³,Marquez-Salinas Alejandro¹²^ORCID,Bourqui Laurent⁴^ORCID,Tellez-Sutterlin Michelle¹⁵,Bahena-Lopez Jessica P.⁶⁷,Cortes-Arroyo Eduardo¹^ORCID,Behn-Eschenburg Sebastián González¹⁵,Lopez-Saavedra Alejandro⁸^ORCID,Vazquez Norma⁵^ORCID,Ellison David H.⁶⁷⁹^ORCID,Loffing Johannes⁴^ORCID,Gamba Gerardo¹²⁵^ORCID,Castañeda-Bueno Maria¹^ORCID

Affiliation:

1. Department of Nephrology and Mineral Metabolism, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico

2. PECEM, Facultad de Medicina, Universidad Nacional Autónoma de México, Mexico City, Mexico

3. Facultad de Medicina, Universidad Nacional Autónoma de México, Mexico City, Mexico

4. Institute of Anatomy, University of Zurich, Zurich, Switzerland

5. Molecular Physiology Unit, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Mexico City, Mexico

6. Division of Nephrology and Hypertension, Department of Medicine, Oregon Health and Science University, Portland, Oregon, United States

7. Oregon Clinical and Translational Research Institute, Oregon Health and Science University, Portland, Oregon, United States

8. Unidad de Aplicaciones Avanzadas en Microscopía del Instituto Nacional de Cancerología y la Red de Apoyo a la Investigación, Universidad Nacional Autónoma de México, Mexico City, Mexico

9. Veterans Affairs Portland Health Care System, Portland, Oregon, United States

Abstract

With-no-lysine kinases regulate the phosphorylation and activity of the Na+-Cl– and Na+-K+-2Cl– cotransporters. This pathway is modulated by arginine vasopressin (AVP). However, the link between AVP and WNK signaling remains unknown. Here, we show that AVP activates WNK4 through increased phosphorylation at putative protein kinase A-regulated sites and decreases its dephosphorylation by protein phosphatase 1. This work increases our understanding of the signaling pathways mediating AVP actions in the kidney.

Funder

Consejo Nacional de Humanidades Ciencias y Tecnologías

Fondation Leducq

HHS | National Institutes of Health

Swiss National Science Foundation

U.S. Department of Veterans Affairs

Universidad Nacional Autónoma de México

Publisher

American Physiological Society

Subject

Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/ajprenal.00343.2023

Reference54 articles.

1. Vasopressin: physiology, assessment and osmosensation

2. Molecular Physiology of Water Balance

3. Regulation of the Abundance of Renal Sodium Transporters and Channels by Vasopressin

4. Regulation of renal Na-(K)-Cl cotransporters by vasopressin