Cannabinoid receptor type 1 activation causes a water diuresis by inducing an acute central diabetes insipidus in mice-Reference-Cited by-同舟云学术

Cannabinoid receptor type 1 activation causes a water diuresis by inducing an acute central diabetes insipidus in mice

Published:2024-06-01 Issue:6 Volume:326 Page:F917-F930
ISSN:1931-857X
Container-title:American Journal of Physiology-Renal Physiology
language:en
Short-container-title:American Journal of Physiology-Renal Physiology

Author:

Rein Joshua L.¹²^ORCID,Mackie Ken³⁴^ORCID,Kleyman Thomas R.⁵⁶⁷^ORCID,Satlin Lisa M.⁸^ORCID

Affiliation:

1. Renal Section, Department of Medicine, James J. Peters Veterans Affairs Medical Center, Bronx, New York, United States

2. Barbara T. Murphy Division of Nephrology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, United States

3. Gill Center for Biomolecular Medicine, Indiana University, Bloomington, Indiana, United States

4. Department of Psychological and Brain Sciences, Indiana University, Bloomington, Indiana, United States

5. Renal-Electrolyte Division, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States

6. Department of Cell Biology, University of Pittsburgh, Pittsburgh, Pennsylvania, United States

7. Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, Pennsylvania, United States

8. Department of Pediatrics, Icahn School of Medicine at Mount Sinai, New York, New York, United States

Abstract

The CB1R agonist WIN55,212-2 induces central diabetes insipidus in mice. This research integrates existing knowledge regarding the diuretic effects of cannabinoids and the influence of CB1R on vasopressin secretion while adding new mechanistic insights about total body water homeostasis. Our findings provide a deeper understanding about the potential clinical impact of cannabinoids on human physiology and may help identify targets for novel therapeutics to treat water and electrolyte disorders such as hyponatremia and volume overload.

Funder

Biomedical Laboratory Research and Development, VA Office of Research and Development

HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases

HHS | NIH | National Institute on Drug Abuse

Publisher

American Physiological Society

Link

https://journals.physiology.org/doi/pdf/10.1152/ajprenal.00320.2022

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